Regression slope of inbreeding coefficient F III on disease status (including confidence interval).

<p>The inbreeding coefficient F III as a continuous variable is used in a generalized linear model as an explanatory variable on the disease status of the study participants defined as the binary response (0/1).</p

Association between overall ROH and HL (min. 75 SNPs per ROH).

<p>Association between overall ROH and HL (min. 75 SNPs per ROH).</p

List of ROHs associated with HL.

<p>List of ROHs associated with HL.</p

Consistently enriched categories of the GWAS on BC survival.

<p>Only categories enriched in all four gene lists and by more than one tool were considered consistently enriched. * Genes present in the 0.01 gene list (allelic SNP <i>p</i>-value cut-off 0.01).</p

Gene overlap of the consistently enriched categories based on the GWAS genes present in the 0.01 gene list.

<p>Gene overlap of the consistently enriched categories based on the GWAS genes present in the 0.01 gene list.</p

Flow chart of the pathway enrichment analysis of the GWAS on BC survival.

<p>Flow chart of the pathway enrichment analysis of the GWAS on BC survival.</p

Distribution of the seven generic terms among the 50 top pathways in the enrichment analyses of the 13 gene lists.

<p>Distribution of the seven generic terms among the 50 top pathways in the enrichment analyses of the 13 gene lists.</p

Additional file 1: Figure S1. of Runs of homozygosity and inbreeding in thyroid cancer

Example for recurrent ROHs in the telomeric region of chromosome 15 for 6 cases. (PDF 335 kb

GeneGo pathway “Cytoskeleton remodeling”.

<p>Barometer: 1 = 0.01 gene list; 2 = general metastasis signature; 3 = brain metastasis signature. orange = ECM-receptor interaction, purple = Adherens junction pathway, red = Calcium signaling pathway, pink = Focal adhesion pathway, yellow = TGF-β signaling pathway, green = Wnt signaling pathway, blue = Smooth muscle contraction/relaxation.</p

Number of SNPs and genes corresponding to allelic <i>p</i>-value cut-offs of the GWAS on BC survival.

<p>Number of SNPs and genes corresponding to allelic <i>p</i>-value cut-offs of the GWAS on BC survival.</p